| Methoxy poly（ethylene glycol）-b-poly（ethyl cyanoacrylate） copolymer nanoparticles as delivery vehicles for dexamethasone |
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| 作者姓名： | ZHAI YingLei DENG LianDong LIN XiaoNa XIAO Li JIN FengMin DONG AnJie |
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| 作者单位： | School of Chemical Engineering and Technology, Tianjin University, ＂l-ianjin 300072, China |
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| 基金项目： | Supported by the Key Project of Tianjin Municipal Natural Science Foundation (Grant No. 08JCZDJC17200);;Tianjin Municipal Natural Science Foundation (Grant No. 08JCYBJC01800);;National Natural Science Foundation of China (Grant No. 30672554) |
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| 摘 要： | Methoxy poly（ethylene oxide）-b-poly（ethyl cyanoacrylate） （mPEG-b-PECA）, amphiphilic block copolymer, was synthesized via oxyanion-initiated polymerization with a sodium alcoholate-terminated monomethoxy poly（ethylene glycol） as the macroinitiator. mPEG-b-PECA was characterized by GPC, 1H-NMR and FTIR. The results indicate that the structure of mPEG-b-PECA is well controlled with narrow molecular weight distribution. The dexamethasone （DXM）-loaded mPEG-b-PECA nanoparticles （NPs） were prepared by the nanoprecipitation technique and characterized by LPSA, 1H-NMR and TEM. The DXM-loaded mPEG-b-PECA NPs are of spherical shape with the size of less than 100 nm. The drug-loaded amount （DL） and encapsulation efficiency （EE） of DXM-loaded NPs were investigated by HPLC. The results show that DXM can be effectively incorporated into mPEG-b-PECA NPs, which provides a potential delivery system for DXM and other hydrophobic drugs.
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| 关 键 词： | 甲氧基聚乙二醇 两亲嵌段共聚物 MPEG 地塞米松 纳米粒子 运载工具 丙烯酸酯 氰基丙烯酸乙酯 |
| 收稿时间： | 2008-09-14 |
| 修稿时间： | 2009-02-18 |
Methoxy poly(ethylene glycol)-b-poly(ethyl cyanoacrylate) copolymer nanoparticles as delivery vehicles for dexamethasone |
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| ZHAI YingLei,DENG LianDong,LIN XiaoNa,XIAO Li,JIN FengMin,DONG AnJie.Methoxy poly(ethylene glycol)-b-poly(ethyl cyanoacrylate) copolymer nanoparticles as delivery vehicles for dexamethasone[J].Chinese Science Bulletin,2009,54(17):2918-2924. |
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| Authors: | YingLei Zhai LianDong Deng XiaoNa Lin Li Xiao FengMin Jin AnJie Dong |
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| Institution: | School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China |
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| Abstract: | Methoxy poly(ethylene oxide)-b-poly(ethyl cyanoacrylate) (mPEG-b-PECA), amphiphilic block copolymer, was synthesized via oxyanion-initiated polymerization with a sodium alcoholate-terminated monomethoxy poly(ethylene glycol) as the macroinitiator. mPEG-b-PECA was characterized by GPC, 1H-NMR and FTIR. The results indicate that the structure of mPEG-b-PECA is well controlled with narrow molecular weight distribution. The dexamethasone (DXM)-loaded mPEG-b-PECA nanoparticles (NPs) were prepared by the nanoprec... |
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| Keywords: | poly(ethylene glycol) poly(ethyl cyanoacrylate) amphiphilic diblock copolymers nanoparticles drug delivery system |
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