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More on the need for circadian, circaseptan and circannual optimization of cyclosporine therapy |
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| Authors: | T Liu M Cavallini F Halberg G Cornelissen J Field D E Sutherland |
| Abstract: | Cyclosporine chronotherapy of pancreas-allotransplanted rats revealed, beyond a circadian stage-dependence of equal daily doses, further gain in graft function from doses varying from day to day with an about 7-day periodicity, the first highest dose being given on the 3rd or 5th day after surgery. |
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