| Keggin结构杂多蓝配合物抗艾滋病病毒（HIV－1）活性研究（Ⅱ） |
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| 引用本文： | 刘术侠,刘彦勇,王恩波,曾毅,李泽琳. Keggin结构杂多蓝配合物抗艾滋病病毒（HIV－1）活性研究（Ⅱ）[J]. 东北师大学报(自然科学版), 1996, 0(1) |
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| 作者姓名： | 刘术侠 刘彦勇 王恩波 曾毅 李泽琳 |
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| 作者单位： | 东北师范大学化学系，中国预防医学科学院 |
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| 摘 要： | 对钨磷、钨硅、铝磷、钼硅四种Ｋｅｇｇｉｎ结构杂多蓝进行了细胞毒性实验．抑制ＭＴ-４细胞增殖实验及抗艾滋病病毒活性实验．结果表明：Ｋｅｇｇｉｎ结构杂多蓝配合物具有较低的细胞毒性及较强的抗艾滋病病毒活性，其中钨硅和钨磷两电子杂多蓝对由艾滋病病毒引起的细胞病变作用（ＣＰＥ）具有较强的抑制活性，对ＣＰＥ的半数抑制浓度（ＥＣ５０）明显低于ｐＭ-１９．
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| 关 键 词： | Keggin结构；杂多蓝；抗艾滋病病毒活性 |
Studies on Anti-HIV-1 Activity of Heteropoly Blue Compounds with Keggin Structure |
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| Liu Shuxia, Liu Yanyong, Wang Enbo. Studies on Anti-HIV-1 Activity of Heteropoly Blue Compounds with Keggin Structure[J]. Journal of Northeast Normal University (Natural Science Edition), 1996, 0(1) |
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| Authors: | Liu Shuxia Liu Yanyong Wang Enbo |
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| Abstract: | The experiments on toxicity of MT-4 cell and restraining proliferation ofMT-4 cell and anti-HIV-1 activity with tungstophosphorate, tungstosilicate, molybdophosphorate and molybdosilicate heteropoly blue compounds of rear earth elementswith keggin structure were studied. The results show that heteropoly blue compounds ofrear earth elements with keggin structure are effective restraining agents with lowtoxcity of cell. In which Ze heteropoly blue compounds of tungstosilicate and tungstophosphorate possess high restraining activity on CPE caused by HIV--l. The half rastrainingconcentration to CPE (EC50) is less than that of PM-19. |
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| Keywords: | Keggin structure heteropoly blue anti-HIV activity |
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