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Calcitonin gene related peptide stimulates adenylate cyclase activity in rat striated muscle |
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| Authors: | H. Kobayashi K. Hashimoto S. Uchida J. Sakuma K. Takami M. Tohyama F. Izumi H. Yoshida |
| Affiliation: | (1) Department of Pharmacology I, Osaka University Medical School, Osaka, Japan;(2) Department of Neuroanatomy, Institute of Higher Nervous Activity, Osaka University Medical School, Osaka, Japan;(3) Department of Pharmacology, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan;(4) Department of Pharmacology I, Osaka University Medical School, Nakanoshima, Kita-ku, 530 Osaka, Japan |
| Abstract: | Summary Rat calcitonin gene related peptide (CGRP) and salmon calcitonin (CT) stimulated adenylate cyclase activity in a dose-dependent manner in the rat diaphragm and in the kidney. The ED50 value of rat CGRP was lower and that of salmon CT was higher in the diaphragm than in the kidney. These results suggest that CGRP stimulates adenylate cyclase activity in the striated muscle by reacting with sites distinct from the site in the kidney. |
| Keywords: | CGRP caleitonin adenylate cyclase neuromuscular junction neuropeptide |
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