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Lysosomal membrane fragility and catabolism of cytosolic proteins: evidence for a direct relationship |
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| Authors: | M. N. Moore A. Viarengo |
| Affiliation: | (1) Natural Environment Research Council, Institute for Marine Environmental Research, Prospect Place, PL1 3DH The Hoe, Plymouth, England;(2) Istituto di Fisiologia Generale, Universita di Genova, Palazzo delle Scienze, Corso Europa, Genova, Italy |
| Abstract: | Summary A direct relationship was established between the stability of the lysosomal membrane and an estimate of cytosolic protein catabolism, based on loss of radiolabel from prelabeled protein. Lysosomes in the lysosomally-rich digestive cells of the midgut gland of the marine mussel (Mytilus edulis) were destabilized by experimental treatment with phenanthrene. |
| Keywords: | Lysosomes lysosomal stability protein catabolism digestive cells marine mussel phenanthrene |
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