Dps-like proteins: structural and functional insights into a versatile protein family |
| |
Authors: | Teemu Haikarainen Anastassios C Papageorgiou |
| |
Institution: | 1. Turku Centre for Biotechnology, University of Turku and ?bo Akademi University, Biocity, P.O. Box 123, Turku, 20521, Finland
|
| |
Abstract: | Dps-like proteins are key factors involved in the protection of prokaryotic cells from oxidative damage. They act by either
oxidizing iron to prevent the formation of oxidative radicals or by forming Dps-DNA complexes to physically protect DNA. All
Dps-like proteins are characterized by a common three-dimensional architecture and are found as spherical dodecamers with
a hollow central cavity. Despite their structural similarities, recent biochemical and structural data have suggested different
functions among members of the family that range from protection inside the cells in response to various stress signals to
adhesion and virulence during bacterial infections. Moreover, the Dps-like proteins have lately attracted considerable interest
in the field of nanotechnology owing to their ability to act as protein cages for iron and various other metals. A better
understanding of their function and mechanism could therefore lead to novel applications in biotechnology and nanotechnology. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|