Inhibition of brain enolases by acrylamide and its related compounds in vitro, and the structure-activity relationship |
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Authors: | H Tanii K Hashimoto |
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Abstract: | Acrylamide and its related compounds inhibited brain enolases in vitro independently of their neurotoxicity. The inhibitory potency was a function of the binding constants of the compounds for phenylalanine. The binding constant for tryptophan was higher in neurotoxic compounds than in non-neurotoxic ones. |
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