Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity |
| |
Authors: | Harvey Natasha L Srinivasan R Sathish Dillard Miriam E Johnson Nicole C Witte Marlys H Boyd Kelli Sleeman Mark W Oliver Guillermo |
| |
Affiliation: | Department of Genetics and Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105-2794, USA. |
| |
Abstract: | Multiple organs cooperate to regulate appetite, metabolism, and glucose and fatty acid homeostasis. Here, we identified and characterized lymphatic vasculature dysfunction as a cause of adult-onset obesity. We found that functional inactivation of a single allele of the homeobox gene Prox1 led to adult-onset obesity due to abnormal lymph leakage from mispatterned and ruptured lymphatic vessels. Prox1 heterozygous mice are a new model for adult-onset obesity and lymphatic vascular disease. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|