Capping of concanavalin A- or ricin-binding sites does not influence phagocytosis in polymorphonuclear leukocytes |
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| Authors: | M. E. Feigenson M. Baggiolini H. P. Schnebli |
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| Affiliation: | (1) Research Institute Wander, a Sandoz Research Unit, Wander Ltd., P. O. Box 2747, CH-3001 Berne, (Switzerland);(2) Friedrich Miescher Institute, CH-4000 Basel, (Switzerland) |
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| Abstract: | Summary Rabbit polymorphonuclear leukocytes (PMNs) were capped with territin-conjugated concanavalin A or ricin, and then allowed to phagocytose yeast cells. Phagocytic activity and lectin distribution were determined by ultrastructural morphometry. Capped PMNs were found to phagocytose as efficiently as control PMNs, and always to ingest the particles with a lectin-free portion of their plasma membrane. This clearly indicates that concanavalin A- and ricin-binding sites of the PMN membrane are not involved in the recognition and phagocytosis of yeast particles. |
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