| 有机相酶催化合成单甘酯对映体的研究 |
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| 引用本文： | 王静,王芳,谭天伟,邓利. 有机相酶催化合成单甘酯对映体的研究[J]. 北京化工大学学报(自然科学版), 2009, 36(5): 70-73 |
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| 作者姓名： | 王静 王芳 谭天伟 邓利 |
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| 作者单位： | 北京化工大学,生命科学与技术学院,北京,100029;北京化工大学,生命科学与技术学院,北京,100029;北京化工大学,生命科学与技术学院,北京,100029;北京化工大学,生命科学与技术学院,北京,100029 |
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| 基金项目： | 国家"863"计划，国家自然科学基金，国家"973"计划 |
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| 摘 要： | 以固定化脂肪酶Novozym435为催化剂，有机溶剂为反应介质，油酸、甘油反应合成手性单甘酯，考察了溶剂对单甘酯的对映体选择性酯化反应的影响。分析了对映体过量值ee与溶剂的物性参数（疏水性LogP、介电常数ε、分子体积、溶解度参数δ）的相关性，结果表明，ee值与溶剂的分子体积、LogP都呈负相关性，在小分子溶剂或高极性溶剂体系，可获得较高ee值。
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| 关 键 词： | 脂肪酶 对映体 有机溶剂 单甘酯 |
| 收稿时间： | 2009-02-25 |
Enzymatic synthesis of monoacylglycerol isomers in organic solvents |
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| WANG Jing,WANG Fang,TAN TianWei,DENG Li. Enzymatic synthesis of monoacylglycerol isomers in organic solvents[J]. Journal of Beijing University of Chemical Technology, 2009, 36(5): 70-73 |
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| Authors: | WANG Jing WANG Fang TAN TianWei DENG Li |
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| Affiliation: | College of Life Science and Technology,Beijing University of Chemical Technology, Beijing 100029, China |
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| Abstract: | The immobilized lipase Novozym 435-catalyzed synthesis of chiralmonoacylglycerol (MAG) was carried out via esterification of oleic acid with glycerol in various organic solvents, and the solvent effects on the enantioselective esterification were investigated. The correlation of the enantiomeric excess (ee) of MAG with the solvent properties as hydrophobicity (Log P), dielectric constant (ε), molecular volume and Hildebrand solubility parameter (δ) were studied. A significant negative correlation between ee and both the molecular volume and Log P were observed. The highest ee was obtained in solvents with small molecular size or high polarity. |
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| Keywords: | lipase isomer solvent monoacylglycerol |
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