The Membrane Protein Data Bank |
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| Authors: | P Raman V Cherezov M Caffrey |
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| Institution: | (1) College of Science and Materials and Surface Science Institute, University of Limerick, Limerick, Ireland;(2) Biophysics Program, The Ohio State University, Columbus, Ohio 43210, USA;(3) Chemistry Department, The Ohio State University, Columbus, Ohio, 43210, USA |
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| Abstract: | The Membrane Protein Data Bank (MPDB) is an online, searchable, relational database of structural and functional information
on integral, anchored and peripheral membrane proteins and peptides. Data originates from the Protein Data Bank and other
databases, and from the literature. Structures are based on X-ray and electron diffraction, nuclear magnetic resonance and
cryoelectron microscopy. The MPDB is searchable online by protein characteristic, structure determination method, crystallization
technique, detergent, temperature, pH, author, etc. Record entries are hyperlinked to the PDB and Pfam for viewing sequence,
three-dimensional structure and domain architecture, and for downloading coordinates. Links to PubMed are also provided. The
MPDB is updated weekly in parallel with the Protein Data Bank. Statistical analysis of MPDB records can be performed and viewed
online. A summary of the statistics as applied to entries in the MPDB is presented. The data suggest conditions appropriate
for crystallization trials with novel membrane proteins.
Received 3 August 2005; received after revision 18 September 2005; accepted 26 September 2005
This paper and the Membrane Protein Data Bank celebrate the 20th anniversary of the landmark paper in Nature (1985, 318: 618–624) describing the first ‘high-resolution’ three-dimensional structure of a membrane protein, the photosynthetic reaction
center from Rhodopseudomonas (Blastochloris) viridis. |
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| Keywords: | Channels lipids receptors relational database transporters |
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