卵巢切除术对大鼠子宫内膜异位症的影响

目的：利用大鼠子宫内膜异位症动物模型，观察卵巢切除术对大鼠子宫内膜异位症的影响。方法：47只大鼠在建模后3周，第2次剖腹，观察移植物的生长情况和体积。将已成模大鼠随机分为两组：对照组（n＝23）和卵巢切除术组（n＝24），对卵巢切除术组大鼠行双侧卵巢切除，分别观察两组动物成模后2、4、6和8周移植物的生长情况和体积。结果：与建模后3周时相比，成模后2、4、6和8周对照组大鼠移植物的生长情况和体积基本保持一致，而卵巢切除术组大鼠异位子宫内膜出现萎缩退化并且体积明显缩小，术后4、6和8周与术后2周相比，作用更明显，百术后4、6和8周之间无明显差异，术后8周仍可见异位内膜组织存在。组织学检查，对照组大鼠异位子宫内膜呈增生状态，而卵巢切除术组呈萎缩状态。结论：卵巢切除术可使子宫内膜异位症大鼠异位子宫内膜逐渐萎缩退化，但未能使其消失。

Effects of ovariectomy on experimentally induced endometriosis in the rat

Aim: To characterize the effect of ovariectomy on endometriosis explant using the rat model. WTHZ Methods:WTBZ Endometriosis was induced in mature female rats. They were divided in two groups -- ovariectomies (n=23) and controls (n=24). The rats were killed at 2, 4, 6 and 8 weeks of ovariectomy at which time the explant was evaluated. WTHZ Results: WTBZExplant volume was significantly reduced in all ovariectomy groups, an effect that was more significant in animals for 4, 6, 8 weeks compared with those for only 2 weeks. Histologic examination of the explants demonstrated a proliferation in the control group and an atrophy in the ovariectomy group.WTHZ Conclusion:WTBZ Ovariectomy caused gradual regression of endometrial explant, but it can not produce a complete regression of the endometrial explant.