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A new model of glucocorticoid-induced metanephric maldevelopment |
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| Authors: | E. D. Avner W. E. Sweeney Jr N. P. Piesco D. Ellis |
| Affiliation: | (1) Protein and Renal Organ Culture laboratory, Children's Hospital, of Pittsburgh, 15213 Pittsburgh, Pennsylvania, USA;(2) Departments of Pediatrics and Anatomy-Histology, University of Pittsburgh Schools of Medicine and Dental Medicine, 15213 Pittsburgh, Pennsylvania, USA;(3) Division of Nephrology, Children's Hospital of Pittsburgh, 125 DeSoto Street, 15213 Pittsburgh, Pennsylvania, USA |
| Abstract: | Summary A new experimental model of glucocortocoid-induced tubular cyst formation has been developed in metanephric organ culture. The addition of cortisol (1.4×10–5 M) to chemically defined serum-free culture medium produces cystic changes during in vitro nephrogenesis. The model isolates the role of glucocorticoids in experimental cyst formation.Acknowledgment. This work has been supported by Basil O'Connor Starter Research Grant No.5-349 from the March of Dimes Birth Defects Foundation. |
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