Different functional outcomes of intercellular membrane transfers to monocytes and T cells |
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Authors: | Kiave-Yune HoWangYin Estibaliz Alegre Marina Daouya Benoit Favier Edgardo D Carosella Joel LeMaoult |
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Institution: | (1) CEA, I2BM, Service de Recherches en Hemato-Immunologie, 75475 Paris, France;(2) Institut Universitaire d’Hematologie, Hopital Saint Louis, 75475 Paris, France;(3) Department of Biochemistry, University Clinic of Navarra, Pamplona, Spain;(4) CEA-I2BM-SRHI, Hopital Saint Louis, 1 Avenue Claude Vellefaux, 75010 Paris, France; |
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Abstract: | Trogocytosis is the uptake of membranes from one cell by another. Trogocytosis has been demonstrated for monocytes, B cells,
T cells, and NK cells. The acquisition of the tolerogenic molecule HLA-G by T cells and NK cells makes them behave as regulatory
cells. We investigated here whether HLA-G, which is expressed by tumor cells in vivo, could be acquired by monocytes and if
this transfer could have functional consequences. We demonstrate that resting, and even more so, activated monocytes efficiently
acquire membrane-bound HLA-G from HLA-G tumor cells by trogocytosis. However, we demonstrate that HLA-G quickly disappears
from the surface of the monocytes in contrast to the HLA-G acquired by T cells. Consequently, HLA-Gacq+ monocytes do not reliably inhibit the on-going proliferation of autologous activated T cells and do not inhibit their cytokine
production. Thus, we show that the acquirer cell may control the functional outcome of trogocytosis. |
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