|
|||||
|
|
Identification of two related pentapeptides from the brain with potent opiate agonist activity. |
|
| Authors: | J Hughes T W Smith H W Kosterlitz L A Fothergill B A Morgan H R Morris |
| Abstract: | Enkephalin, a natural ligand for opiate receptors is composed of the pentapepides H-Tyr-Gly-Gly-Phe-Met-OH and H-Tyr-Gly-Gly-Phe-Leu-OH. The evidence is based on the determination of the amino acid sequence of natural enkephalin by the dansyl-Edman procedure and by mass spectrometry followed by synthesis and comparison of the natural and synthetic peptides. |
| Keywords: | |