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Common variants in ZNF365 are associated with both mammographic density and breast cancer risk |
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| Authors: | Lindström Sara Vachon Celine M Li Jingmei Varghese Jajini Thompson Deborah Warren Ruth Brown Judith Leyland Jean Audley Tina Wareham Nicholas J Loos Ruth J F Paterson Andrew D Rommens Johanna Waggott Darryl Martin Lisa J Scott Christopher G Pankratz V Shane Hankinson Susan E Hazra Aditi Hunter David J Hopper John L Southey Melissa C Chanock Stephen J Silva Isabel dos Santos Liu JianJun Eriksson Louise Couch Fergus J Stone Jennifer Apicella Carmel Czene Kamila Kraft Peter Hall Per Easton Douglas F Boyd Norman F Tamimi Rulla M |
| Institution: | Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. |
| Abstract: | High-percent mammographic density adjusted for age and body mass index is one of the strongest risk factors for breast cancer. We conducted a meta analysis of five genome-wide association studies of percent mammographic density and report an association with rs10995190 in ZNF365 (combined P = 9.6 × 10(-10)). Common variants in ZNF365 have also recently been associated with susceptibility to breast cancer. |
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