Apoptosis regulation in the mammary gland |
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Authors: | Green K A Streuli C H |
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Institution: | (1) School of Biological Sciences, University of Manchester, Stopford Building, Oxford Road, M13 9PT Manchester, United Kingdom |
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Abstract: | Epithelial apoptosis has a key role in the development and function of the mammary gland. It is involved with
the formation of ducts during puberty and is required to remove excess epithelial cells after lactation so that
the gland can be prepared for future pregnancies. Deregulated apoptosis contributes to malignant progression in
the genesis of breast cancer. Since epithelial cell apoptosis in the lactating mammary gland can be synchronised
by forced weaning, it has been possible to undertake biochemical analysis of the pathways involved. Together with
the targeted overexpression or deletion of candidate genes, these approaches have provided a unique insight into
the complex mechanisms of apoptosis regulation in vivo. This review explores what is currently known about the
triggers for apoptosis in the normal mammary gland, and how they link with the intrinsic apoptotic machinery.Received 23 September 2003; received after revision 13 February 2004; accepted 3 March 2004 |
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Keywords: | Mammary gland breast apoptosis involution development epithelia |
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