| 2—羟甲基—4—甲氧基—3，5—二甲基吡啶的合成 |
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| 引用本文： | 刘德龙,刘蕴,王苏惠,戴桂元. 2—羟甲基—4—甲氧基—3，5—二甲基吡啶的合成[J]. 徐州师范大学学报(自然科学版), 2003, 21(1): 46-48 |
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| 作者姓名： | 刘德龙 刘蕴 王苏惠 戴桂元 |
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| 作者单位： | 徐州师范大学,化学系,江苏,徐州,221116 |
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| 摘 要： | 以2，3，5－三甲吡啶为原料，经N－氧化，硝化，甲氧基取代，乙酰化，水解五步反应合成2－羟甲基－4－甲氧基－3，5－二甲基吡啶，总收率达69．7％。
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| 关 键 词： | 2 3 5三甲基吡啶 2－羟甲基－4－甲氧基－3 5－二甲基吡啶 合成 |
| 文章编号： | 1007-6573(2003)01-0046-03 |
| 修稿时间： | 2002-12-05 |
The Synthesis of 2-hydroxymethyl-4-methoxy-3,5-dimethylpyridine |
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| LIU De-long,LIU Yun,WANG Su-hui,DAI Gui-yuan. The Synthesis of 2-hydroxymethyl-4-methoxy-3,5-dimethylpyridine[J]. Journal of Xuzhou Normal University(Natural Science Edition), 2003, 21(1): 46-48 |
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| Authors: | LIU De-long LIU Yun WANG Su-hui DAI Gui-yuan |
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| Abstract: | 2-hydroxymethyl-4-methoxy-3, 5-dimethylpyridine, an intermediate of Omprazole and Esomprazole, was synthesized from 2,3,5-trimethylpyridine by N-oxidation, nitration, and methoxy-lation to give the 4-methoxy-3, 5-dimethylpyridine-N-oxide, which was then treated with acetic anhydride and followed by hydrolysis using dilute hydrochloric acid as hydrolytic reagent to give the title compound. The overall yield reached 69. 7% and the method had the advantage of mild reaction, low cost and waste. |
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| Keywords: | 2 3 5-trimethylpyridine 2-hydroxymethyl-4-methoxy-3 5-dimethylpyridine synthesis |
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