Use of indomethacin to reverse neonatal hypotension

Summary Treatment with indomethacin elevated systemic arterial pressure and pulmonary vascular resistance in hypotensive newborn goats. Indomethacin may be of value in restoration of systemic arterial pressure in stress-induced hypotension.Supported in part by Nos. NIH-HL-10834-06, NIH-T01-HL05979-02S1 and Florida Heart No. 74-AG-2.Acknowledgments. The authors wish to thankN. L. Murtha, L. Tumarkin, J. Howard andP. Eitzman for their technical assistance and Merck, Sharpe and Dohme for the gift of indomethacin. This research was conducted under the guiding principles in the care and use of animals approved by the Council of the American Physiological Society and the National Institute of Health.