| Molecular structure and biological function of proliferating cell nuclear antigen |
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| 作者姓名： | Song Nanmeng Sang Jianli and Xu Heng |
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| 作者单位： | 1. Institute of Cell Biology，College of Life Science，Beijing Normal University，Beijing 100875，China; 2. Emory University School of Medicine，GA 30332，USA |
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| 摘 要： | Proliferating cell nuclear antigen (PCNA) is the core component of replication complex in eukaryote. As a processive factor of DNA polymerase delta, PCNA coordinates the replication process by interacting with various replication proteins. PCNA appears to play an essential role in many cell events, such as DNA damage repair, cell cycle regulation, and apoptosis, through the coordination or organization of different partners. PCNA is an essential factor in cell proliferation, and has clinical significance in tumor research. In this article we review the functional structure of PCNA, which acts as a function switch in different cell events.
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Molecular structure and biological function of proliferating cell nuclear antigen |
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| Song Nanmeng,Sang Jianli and Xu Heng.Molecular structure and biological function of proliferating cell nuclear antigen[J].Progress in Natural Science,2007,17(10):1127-1135. |
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| Authors: | Song Nanmeng Sang Jianli and Xu Heng |
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| Abstract: | Proliferating cell nuclear antigen (PCNA) is the core component of replication complex in eukaryote. As a processive factor of DNA polymerase delta, PCNA coordinates the replication process by interacting with various replication proteins. PCNA appears to play an essential role in many cell events, such as DNA damage repair, cell cycle regulation, and apoptosis, through the coordination or organization of different partners. PCNA is an essential factor in cell proliferation, and has clinical significance in tumor research. In this article we review the functional structure of PCNA, which acts as a function switch in different cell events. |
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| Keywords: | PCNA Function Switch PCNA Binding Motif Cell Cycle DNA Replication DNA Repair |
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