| 一种有机小分子催化剂的合成及其催化的不对称羟醛=缩合反应 |
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| 引用本文： | 金秋,谢黎霞,谢普会,徐翠莲.一种有机小分子催化剂的合成及其催化的不对称羟醛=缩合反应[J].山西大学学报(自然科学版),2010,33(1). |
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| 作者姓名： | 金秋 谢黎霞 谢普会 徐翠莲 |
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| 作者单位： | 河南农业大学理学院应用化学系,河南郑州,450002 |
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| 摘 要： | 以L-脯氨酸为原料,通过氨基保护,羧基酯化,格氏反应,去保护等5步反应得到手性催化剂6,5步的总产率为43%;其结构经HNMR确证.化合物6对映选择性催化直接羟醛反应,产率高迭80%以上;ee值高达60%以上.
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| 关 键 词： | 不对称合成 有机小分子催化 L-脯氨酸 脯氨酸衍生物 |
Synthesis of a Small Organic Molecule and Its Application to Asymmetric Aldol Reaction |
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| JIN Qiu,XIE Li-xia,XIE Pu-hui,XU Cui-lian.Synthesis of a Small Organic Molecule and Its Application to Asymmetric Aldol Reaction[J].Journal of Shanxi University (Natural Science Edition),2010,33(1). |
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| Authors: | JIN Qiu XIE Li-xia XIE Pu-hui XU Cui-lian |
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| Institution: | JIN Qiu,XIE Li-xia,XIE Pu-hui,XU Cui-lian (Department of Chemistry,College of science,Henan Agricultural University,Zhengzhou 450002,China) |
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| Abstract: | A kind of proline-derived small molecules were synthesized in five steps from L-proline though the reaction sequence of protection,condensation,and its chemical structure was characterized by 1H NMR.Compand 6 efficiently catalyzed the direct asymmetric aldol reaction with the yield up to 80% and enantiomeric excess up to 60%. |
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| Keywords: | symmetric synthesis organocatalysis L-proline proline-derives |
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