| 红霉素肟主杂质的分离和鉴定 |
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| 引用本文： | 叶东,邓志华,梁建华,金小红,白景瑞,姚国伟. 红霉素肟主杂质的分离和鉴定[J]. 北京理工大学学报, 2002, 22(2): 244-246. DOI: 10.3969/j.issn.1001-0645.2002.02.030 |
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| 作者姓名： | 叶东 邓志华 梁建华 金小红 白景瑞 姚国伟 |
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| 作者单位： | 北京理工大学,化工与材料学院,北京,100081 |
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| 基金项目： | 国家经贸委技术创新项目;; |
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| 摘 要： | 深入研究了红霉素的肟化反应.分离和鉴定了在合成红霉素肟的过程中产生的一种主要杂质,通过IR,UV,MS,1H NMR和13C NMR确证它和红霉素在酸性水解时生成的红霉素A 8,9-脱水-6,9-半缩酮为同一化合物.这一结果说明,在酸的存在下,红霉素的肟化反应总是伴随有它的酸性降解反应.因此,在合成红霉素肟时,严格控制作为催化剂的酸的用量是极为重要的.
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| 关 键 词： | 红霉素肟 红霉素A 6,9-半缩酮 红霉素A 8,9-脱水-6,9-半缩酮 |
| 文章编号： | 1001-0645(2002)02-0244-03 |
| 收稿时间： | 2001-08-30 |
Separation and Identification of the Main Impurity in Erythromycin Oxime |
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| YE Dong,DENG Zhi hu,LIANG Jian hu,JIN Xiao hong,BAI Jing rui and YAO Guo wei. Separation and Identification of the Main Impurity in Erythromycin Oxime[J]. Journal of Beijing Institute of Technology(Natural Science Edition), 2002, 22(2): 244-246. DOI: 10.3969/j.issn.1001-0645.2002.02.030 |
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| Authors: | YE Dong DENG Zhi hu LIANG Jian hu JIN Xiao hong BAI Jing rui YAO Guo wei |
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| Affiliation: | School of Chemical Engineering and Materials Science, Beijing Institute of Technology, Beijing100081, China;School of Chemical Engineering and Materials Science, Beijing Institute of Technology, Beijing100081, China;School of Chemical Engineering and Materials Science, Beijing Institute of Technology, Beijing100081, China;School of Chemical Engineering and Materials Science, Beijing Institute of Technology, Beijing100081, China;School of Chemical Engineering and Materials Science, Beijing Institute of Technology, Beijing100081, China;School of Chemical Engineering and Materials Science, Beijing Institute of Technology, Beijing100081, China |
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| Abstract: | The oximation of erythromycin is studied. The main impurity involved in the synthesis of erythromycin oxime was separated and purified, which was identified as the very compound formed in the acidic hydrolysis of erythromycin A, i.e erythromycin A 8,9 dehydro 6,9 hemiketal. This result shows that the oximation of erythromycin is always accompanied with its acidic degradation, and therefore that it is important to control the amount of acid used as catalyst. |
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| Keywords: | erythromycin oxime erythromycin A 6 9 hemiketal erythromycin A 8 9 dehydro 6 9 hemiketal |
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