| 胡椒酸丁二醇单酯的合成及其降血脂作用研究 |
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| 引用本文： | 宝贵荣,博·格日勒图,那日苏,韩景芬,昭日格图.胡椒酸丁二醇单酯的合成及其降血脂作用研究[J].内蒙古大学学报(自然科学版),2009,40(1). |
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| 作者姓名： | 宝贵荣 博·格日勒图 那日苏 韩景芬 昭日格图 |
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| 作者单位： | 1. 内蒙古大学高分子化学及蒙药研究所,呼和浩特,010021;呼和浩特职业学院生物化学工程学院,呼和浩特,010051
2. 内蒙古大学高分子化学及蒙药研究所,呼和浩特,010021 |
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| 摘 要： | 以蒙药药材荜茇为原料,经过分离、纯化得胡椒碱,进一步水解得胡椒酸.以胡椒酸和丁二醇为原料合成了胡椒酸丁二醇单酯,经13CNMR、1HNMR、UV、IR、EA表征后确证结构并做了一般药理实验,实验结果表明目标化合物具有良好的降血脂活性.
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| 关 键 词： | 荜茇 降血脂作用 胡椒酸酯 胡椒碱 |
Synthesis of a Butanediol Piperic Monoester and Its Anti-hyperlipidemia Activity |
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| BAO Gui-rong,Gereltu Borjihan,Narisu,HAN Jing-fen,Zhaorigrtu.Synthesis of a Butanediol Piperic Monoester and Its Anti-hyperlipidemia Activity[J].Acta Scientiarum Naturalium Universitatis Neimongol,2009,40(1). |
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| Authors: | BAO Gui-rong Gereltu Borjihan Narisu HAN Jing-fen Zhaorigrtu |
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| Institution: | BAO Gui-rong1,2,Gereltu Borjihan1,Narisu1,HAN Jing-fen1,Zhaorigrtu1 |
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| Abstract: | Piperic acid was obtained by hydrolyzing Piperine that was extracted from seeds of Piper Longum L(Traditional medicine of Mongolian).Using Piperic acid and butanediol as the raw materials to synthesize butanediol piperic monoester,and then the title compound was identified by the HPLC,13CNMR,1HNMR,UV,IR spectrum and elemental analysis.Pharmacological experiments showed that this compound had high anti-hyperlipidemia activity. |
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| Keywords: | Piper longum L anti-hyperlipidemia Piperic ester Piperine |
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