Expression ofbcl-2 gene increases in apoptosis of vascular endothelial cells induced by rattlesnake venom |
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Authors: | Junying Miao Araki Satohiko Shangli Zhang Hayashi Hiroshi |
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Institution: | (1) Institute of Developmental Biology, School of Life Science, Shandong University, 250100 Jinan, China;(2) Sugashima Marine Biological Laboratory, School of Science, Nagoya University, Toba, 517 Mie, Japan |
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Abstract: | Apoptosis of vascular endothelial cells (VEC) has been induced by deprivation of survival factors (aFGF and serum) and by
rattlesnake venom. The expression ofbcl-2 gene has been examined by Northern blotting in the two apoptosis inducing systems. Our results show that the expression ofbcl-2 has not been detected in normal culture cells and in apoptotic cells induced by deprivation of survival factors. But in apoptotic
cells induced by rattlesnake venom (10 ng/mL), the expression ofbcl-2 increases, and its mRNA exhibits two bands. The data first suggest that increasing expression and splitting ofbcl-2 mRNA may play an important role in apoptosis of VEC induced by rattlesnake venom, and this finding is helpful to understanding
the role ofbcl-2 in regulation of apoptosis. |
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Keywords: | bcl-2 gene rattlesnake venom apoptosis vascular endothelial cells |
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