Bis(7)-tacrine ameliorates cognitive impairment caused by cerebral hypoperfusion in rats |
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| Authors: | Peng Fang-fang Zhang Bai-fang Zhang Jiang-zhou Wu Dong-cheng |
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| Institution: | (1) Department of Biochemistry, School of Medicine, Wuhan University, 430071 Wuhan, Hubei, China |
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| Abstract: | The effects ofbis(7)-tacrine, a novel acetylcholinesterase inhibitor, on cognitive impairment and neuronal degeneration induced by permanent
ligation of bilateral common carotid arteries (2VO) were investigated using the Morris water maze in rats. Once daily oral
administration ofbis(7)-tacrine (0.025, 0.05 and 0.1 mg·kg−1) was started 14 days after 2VO operation. Over a three-week treatmentbis(7)-tacrine effectively reversed 2VO-induced spatial memory deficits in a dose-dependent fashion. Furthermore, histological
observation showedbis(7)-tacrine decreased the neuropathological changes in the 2VO rats brain. These results suggest thatbis(7)-tacrine has therapeutic potential for the treatment of dementia caused by chronic cerebral hypoperfusion.
Foundation item: Supported by the National Natural Science Foundation of China (No: 30170335)
Biography: Peng Feng-fang(1966-), female Master, research direction: Alzheimer's disease and ischemia |
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| Keywords: | bis(7)-tacrine acetylcholinesterase inhibitor permanent bilateral occlusion of common carotid arteries vascular dementia |
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