Chronic cadmium intake results in dose-related excretion of metallothionein in urine |
| |
| Authors: | Z A Shaikh K M Harnett S A Perlin P C Huang |
| |
| Institution: | Department of Pharmacology and Toxicology, University of Rhode Island, Kingston 02881. |
| |
| Abstract: | Urinary excretion of metallothionein was measured by radioimmunoassay in rats given drinking water containing 5 or 50 mg cadmium/l for up to 2 years. The metallothionein levels corresponded to the concentration of cadmium in the drinking water and increased linearly over the course of the study. These results demonstrate that urinary metallothionein is a sensitive biological indicator of oral cadmium exposure. |
| |
| Keywords: | |
|
