Effect of splanchnectomy and vagotomy on the pepsinogen response to intragastric acid |
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| Authors: | D E Webber Shelagh M Morrissey |
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| Institution: | (1) Department of Physiology, Queen Elizabeth College, W8 7AH London, (England);(2) Present address: Department of Medicine, Royal Veterinary College, North Mymms, AL9 7TA Hatfield, Herts, (England) |
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| Abstract: | Summary Perfusion of the stomach in the anaesthetized rat with saline acidified to pH 2.5 with hydrochloric acid induced a small but significant release of pepsinogen into the perfusate. This stumulus to secretion was unaffected by splanchnectomy but was abolished by vagotomy. It is concluded that to a modest degree acid secretion in the rat may stimulate pepsinogen secretion by a vagal pathway. |
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