| 国产盐酸二甲胺四环素对裸鼠体内麻风杆菌的影响 |
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| 引用本文： | 王荷英,李文忠.国产盐酸二甲胺四环素对裸鼠体内麻风杆菌的影响[J].实验动物科学,1996,13(3):34-36. |
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| 作者姓名： | 王荷英 李文忠 |
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| 作者单位： | 中国医学科学院，中国协和医科大学皮肤病研究所 |
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| 摘 要： | 本研究系用麻风裸鼠实验模型，采用动力法投药１０５天，观察了０．０２％二甲胺四环素和０．０４％ＭＩＮＯ的抗麻风杆菌活性，并同０．０２％进口ＭＩＮＯ和已知抗麻风药物０．０２％利福平进行了平行比较，实验结果表明，国产ＭＩＮＯ儿进口ＭＩＮＯ的实验疗效基本一致。而且，随着药物剂量的提高，抑制麻风杆蓖作用增强，在停药早期，以０．０４％ＭＩＮＯ组疗效最佳，显示有部分杀菌活性，显示有部分杀菌活性，但是，随着停药是
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| 关 键 词： | 麻风杆菌 二甲胺四环素 感染 裸鼠 动物实验 |
Activities of home-made minocyclin against M. Ieprae in the nude mice |
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| Wang Heying, Li Wenzhong, Shen Jianping, Si Meiqing, Wang Hongchun Institute of Dermatology,Chinese Academy of Medical Sciences,Peking Union Medical College,Nanjing.Activities of home-made minocyclin against M. Ieprae in the nude mice[J].Shiyan Dongwu Kexue,1996,13(3):34-36. |
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| Authors: | Wang Heying Li Wenzhong Shen Jianping Si Meiqing Wang Hongchun Institute of Dermatology Chinese Academy of Medical Sciences Peking Union Medical College Nanjing [ |
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| Institution: | Wang Heying, Li Wenzhong, Shen Jianping, Si Meiqing, Wang Hongchun Institute of Dermatology,Chinese Academy of Medical Sciences,Peking Union Medical College,Nanjing 210042[ |
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| Abstract: | The activitics of 0.02%and 0.04% homc-madc minocyclin ahainst M. leprae in the nude mice were cvaluat-cd by the kinetic method,and compared with those of 0.02% imported minocyclin and 0.02%rifampin. The nude mice weretreated for 105 days,The results revcalcd that the activity of home-made minocyclin against M. leprac is similar to that of im-ported minocyclin,and the larger the dosage of the drug is,the stronger the activity of the drug shows. During the early peri-od of stopping treatment,0.04% minocyclin showed the best anti-leprosy effect with the part of bactcriocidal activity.How-ever the activity of rifampin against M. leprae was more persistent and stablc than that of minocyclin when the period of stop-ping treatment is prolouged. |
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| Keywords: | nude mice M leprae minocyclin |
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