交叉学科研究推动了生物无机化学学科的发展

本文分为七部分，第一部分对生物无机化学学科发展进行历史回顾；第二部分从回顾史实中用实例表明生物无机化学的研究始终瞄准金属离子和生物配体控制生命过程中的化学问题；第三部分是介绍当今国际上研究核酸领域的争论焦点；第四部分是报导我们设计和合成了作为人工核酸酶的一系列新的配体以及许多不同金属的功能配合物；第五部分是讨论用动力学、热力学和DFT计算方法研究配合物和DNA相互作用的键合机制以及十多种影响因素；第六部分进一步报导配合物的生物功能和它们的应用探索，最后一部分提出在核酸领域的某些新的发展方向和途径。我们进一步提出了配合物的结构与DNA的作用机制以及它们的生物功能之间的规律性。通过配合物的结构改变去调控和改变配合物对DNA键合性质和生物功能。

The Study of Intersection Subject Promotes the Development of Bioinorganic Chemistry Subject

This paper is divided into following seven sections. The first section reviews the development of bioinorganic chemistry subject. The second section, it indicate reviews by some examples from the reviews that the study of bioinorganic chemistry aim throughout at the metal ions and biological ligands control chemical problems in the course of life. The third section introduces the present heated debate focuses in the research field of nucleic acid. The fourth section reports a series of new ligands and their many different metal functional coordination compounds as artificial nucleases were designed and synthesized by author. The fifth section is the discussion of the studies on binding mechanism and more than ten kinds of influence factors of the interactions of coordination compounds with DNA by kinetics, theremodynamics and DFT calculation methods. The sixth section gives a further report of biological function of coordination compounds and their application exploration. The final section is the suggestion of some new development direction and research ways in nucleic acid field. The regulars among the structure of coordination compounds, the interaction mechanism and biological function are suggested further by author. The binding behaviors and biological functions of coordination compounds for DNA can be modulated and changed by the change of structure of coordination compounds.