| 5-氟尿嘧啶类脂囊泡药动学和组织分布研究 |
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| 引用本文： | 袁悦,王觅,谌红丹,车鑫,赵琨,王晶.5-氟尿嘧啶类脂囊泡药动学和组织分布研究[J].东北师大学报(自然科学版),2012,44(2):99-102. |
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| 作者姓名： | 袁悦 王觅 谌红丹 车鑫 赵琨 王晶 |
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| 作者单位： | 1. 沈阳药科大学药学院,辽宁沈阳,110016
2. 沈阳药科大学药学院,辽宁沈阳110016;河北省中医院药剂科,河北石家庄500011 |
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| 基金项目： | 辽宁省博士启动基金资助项目，沈阳市科技局资助项目，辽宁省企业博士后项目 |
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| 摘 要： | 用非离子表面活性剂制备5-氟尿嘧啶(5-Fu)囊泡,并对其进行了小鼠体内药动学和组织分布的研究.采用薄膜分散法制备5-Fu的类脂囊泡,以5-Fu水溶液为对照,尾静脉注射自制5-Fu囊泡和5-Fu水溶液,利用高效液相色谱法检测血浆和各组织中的5-Fu浓度,利用统计学方法计算了5-Fu在小鼠体内的药动学参数及小鼠的组织分布参数.与注射水溶液组相比,5-Fu囊泡组MRT值延长,AUC0～t值增加.组织分布结果显示:5-Fu囊泡在肝、肾中AUC值显著增加；5-Fu囊泡明显延长了5-Fu在体内的作用时间,比普通水溶液具有一定的缓释和提高生物利用度的作用.
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| 关 键 词： | 5-氟尿嘧啶 类脂囊泡 药物动力学 组织分布 |
Study on pharmacokinetic and tissue distribution in mice of 5-flurouracil niosomes |
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| YUAN Yue
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WANG Mi
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CHEN Hong-dan
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CHE Xin
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ZHAO Kun
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WANG Jing.Study on pharmacokinetic and tissue distribution in mice of 5-flurouracil niosomes[J].Journal of Northeast Normal University (Natural Science Edition),2012,44(2):99-102. |
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| Authors: | YUAN Yue WANG Mi CHEN Hong-dan CHE Xin ZHAO Kun WANG Jing |
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| Institution: | 1(1.School of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,China;2.Department of Pharmacy,Hebei Province Traditional Chinese Medicine Hospital,Shijiazhuang 500011,China) |
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| Abstract: | To study the preparation of 5-flurouracil(5-Fu) noisomes and the pharmacokinetics and tissue distribution in mice.5-Fu noisomes were prepared using film dispersion method.5-Fu noisomes and 5-Fu solution were carried out in mice by caudal vein injection.5-Fu concentrations of plasma and various tissues were detected by HPLC methods.Statistical methods were used to calculate the parameters of pharmacokinetics and tissue distribution in mice.Compared to the group of 5-Fu solution,MRT and AUC0~t of 5-Fu niosomes both were increased.Compared with 5-Fu solution,5-Fu niosomes had a sustained release and a improved bioavailability. |
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| Keywords: | 5-Fu niosomes pharmacokinetic tissue distribution |
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