Effects of the optical isomers of 2-amino-3-fluoro-1-phenylpropane (monofluoroamphetamine) hydrochloride on uptake and release of dopamine in rat striatum in vitro

Summary The (+)- and (–)-isomers of the monofluorinated amphetamine 2-amino-3-fluoro-1-phenylpropane were prepared and compared for their ability to stimulate release and to inhibit reuptake of radiolabelled dopamine from rat striatal tissue in vitro. The (+)-isomer was much stronger than the (–)-isomer in both cases.Financial support for this project was supplied by the Medical Research Council of Canada, the Alberta Mental Health Research Fund and the Special Services and Research Committee, University of Alberta Hospital.Acknowledgments. Skilled technical assistance was provided by Ms L. Hiob. The authors also wish to thank Dr W.G. Dewhurst, Department of Psychiatry, and Dr D.F. LeGatt, for their advice and comments.