| 桂利嗪原料药及有关物质的HPLC分析 |
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| 引用本文： | 郭 平,刘玉真,戎欣玉,聂新永.桂利嗪原料药及有关物质的HPLC分析[J].河北科技大学学报,2006,27(3):214-216. |
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| 作者姓名： | 郭 平 刘玉真 戎欣玉 聂新永 |
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| 作者单位： | 河北科技大学化学与制药工程学院,河北石家庄,050018;河北科技大学化学与制药工程学院,河北石家庄,050018;河北科技大学化学与制药工程学院,河北石家庄,050018;河北科技大学化学与制药工程学院,河北石家庄,050018 |
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| 摘 要： | 建立了桂利嗪原料药及有关物质的高效液相色谱测定法,采用C18柱和二极管阵列检测器,检测波长为254 nm,样品中各成分的分离度及检出灵敏度完全满足有关物质限度的测定要求,最低检出限为0.02%(质量分数),方法简单、专属,能有效控制产品质量。
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| 关 键 词： | 桂利嗪 降解产物 高效液相色谱分析 |
| 文章编号： | 1008-1542(2006)03-0214-03 |
| 收稿时间： | 2005/6/9 0:00:00 |
| 修稿时间： | 2005年6月9日 |
Determination of cinnarizine and related substances by HPLC |
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| GUO Ping,LIU Yu-zhen,RONG Xin-yu and NIE Xin-yong.Determination of cinnarizine and related substances by HPLC[J].Journal of Hebei University of Science and Technology,2006,27(3):214-216. |
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| Authors: | GUO Ping LIU Yu-zhen RONG Xin-yu and NIE Xin-yong |
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| Institution: | College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang Hebei 050018, China;College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang Hebei 050018, China;College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang Hebei 050018, China;College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang Hebei 050018, China |
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| Abstract: | A liquid chromatography method with high performance for analyzing cinnarizine and related substance was established.C_(18) column and gradient were adopted at the detection of 254 nm with a diode array detector.Resolution and detectable sensitivity of each constituent in sample satisfies determined demand of related substance.The lowest detectable concentration is 0.02%.This method was found to be simple,selective and effective for quality control. |
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| Keywords: | cinnarizine decomposition products HPLC analyst |
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