Soluble factors and the development of rod photoreceptors |
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Authors: | Levine E M Fuhrmann S Reh T A |
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Institution: | (1) Department of Biological Structure, University of Washington School of Medicine, Box 357420, Seattle (Washington 98195, USA), Fax +1 206 543 1524, e-mail:tomreh@u.washington.edu, US |
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Abstract: | Photoreceptors are the most abundant cell type in the vertebrate neural retina. Like the other retinal neurons and the Müller
glia, they arise from a population of precursor cells that are multipotent and intrinsic to the retina. Approximately 10 years
ago, several studies demonstrated that retinal precursor cells (RPCs) are competent to respond to environmental factors that
promote cell type determination and differentiation. Since those studies, significant effort has been directed at identifying
the molecular nature of these environmental signals and understanding the precise mechanisms they employ to drive RPCs towards
the different retinal fates. In this review, we describe the recent progress toward understanding how environmental factors
influence the development of vertebrate rod photoreceptors. |
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Keywords: | , Retina, signaling factors, retinoic acid, Hedgehog, fibroblast growth factor, epidermal growth factor, ciliary,,,,,neurotrophic factor, |
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