Effect of a restricted diet on the in vitro glucose-induced insulin release of aging rats |
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Authors: | M Castro D Pedrosa J I Osuna |
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Institution: | (1) Department of Biochemistry and Molecular Biology, University of Granada, E-18012 Granada, (Spain);(2) Department of Medicine, Faculty of Medicine, University of Granada, E-18012 Granada, (Spain) |
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Abstract: | To study the effect of a sudden loss of body weight on the -cell function of aging rats, basal and glucose-induced insulin secretion was measured in pancreatic islets obtained from young (2-month-old), adult (12-month-old) and aging (24-month-old) rats, either fed ad libitum or fed a restricted diet (50% caloric restriction). Basal insulin secretion was similar in islets of young, adult and older rats. Glucose stimulated insulin release was significantly reduced in aging rats as compared to young animals. Animals fed a restricted diet showed a prolonged and higher secretory rate during first phase release when compared to animals fed ad libitum. |
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Keywords: | Aging insulin release pancreatic islets dieting |
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