| Institution: | (1) CEA, I2BM, Service de Recherches en Hemato-Immunologie, 75475 Paris, France;(2) UMR_E, Universite Paris 7, IUH, Hopital Saint-Louis, Paris, France;(3) Department of Regenerative Medicine, Stem Cells, and Gene Therapy, San Raffaele Telethon Institute for Gene Therapy (HSR-TIGET), Milan, Italy;(4) CEA-SRHI, Hopital St. Louis, 1 Av Claude Vellefaux, 75010 Paris, France |
| Abstract: | The non-classical HLA class I molecule HLA-G was initially shown to play a major role in feto–maternal tolerance. Since this
discovery, it has been established that HLA-G is a tolerogenic molecule which participates to the control of the immune response.
In this review, we summarize the recent advances on (1) the multiple structures of HLA-G, which are closely associated with
their role in the inhibition of NK cell cytotoxicity, (2) the factors that regulate the expression of HLA-G and its receptors,
(3) the mechanism of action of HLA-G at the immunological synapse and through trogocytosis, and (4) the generation of suppressive
cells through HLA-G. Moreover, we also review recent findings on the non-immunological functions of HLA-G in erythropoiesis
and angiogenesis. |
