Peptide antigens for gamma/delta T cells |
| |
Authors: | Willi K Born Li Zhang Maki Nakayama Niyun Jin Jennifer L Chain Yafei Huang M Kemal Aydintug Rebecca L O’Brien |
| |
Affiliation: | (1) Integrated Department of Immunology, National Jewish Health, 1400 Jackson Street, GB K409, Denver, CO 80206, USA;(2) Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA;(3) University of Colorado Denver, Aurora, CO 80045, USA |
| |
Abstract: | γδ T cells express adaptive antigen receptors encoded by rearranging genes. Their diversity is highest in the small region
of TCR V–J junctions, especially in the δ chain, which should enable the γδ TCRs to distinguish differences in small epitopes.
Indeed, recognition of small molecules, and of an epitope on a larger protein has been reported. Responses to small non-peptides
known as phospho-antigens are multi-clonal yet limited to a single γδ T cell subset in humans and non-human primates. Responses
to small peptides are multi-clonal or oligo-clonal, include more than one subset of γδ T cells, and occur in rodents and primates.
However, less effort has been devoted to investigate the peptide responses. To settle the questions of whether peptides can
be ligands for the γδ TCRs, and whether responses to small peptides might occur normally, peptide binding will have to be
demonstrated, and natural peptide ligands identified. |
| |
Keywords: | |
本文献已被 PubMed SpringerLink 等数据库收录! |
|