Systemic candidiasis fromCandida albicans colonizing the gastrointestinal tract of mice |
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| Authors: | T Umenai S Konno N Ishida |
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| Institution: | (1) Department of Bacteriology, Tohoku University School of Medicine, 2-1 Seiryo-machi, 980 Sendai, Japan |
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| Abstract: | Summary Reproducible induction of systemicCandida infection was achieved by treating mice in whichCandida colonization had been established in the gastrointestinal tract by aminobenzylpenicillin treatment. Systemic candidiasis was induced in these mice by X-ray irradiation followed by immunosuppressive doses of dexamethasone or X-ray irradiation followed by immunosuppressive doses of trypan blue. Macrophages seem to play an important role in this systemic infection. |
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