Conversion of psoralen DNA monoadducts in E. coli to interstrand DNA cross links by near UV light (320–360 nm): Inability of angelicin to form cross links,in vivo |
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| Authors: | M J Ashwood-Smith Elizabeth Grant |
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| Institution: | (1) Department of Biology, University of Victoria, V8W 2Y2 Victoria, B. C., Canada |
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| Abstract: | Summary Both angelicin and psoralen monoadducts formed in vivo in E. coli by near UV light produce lethal and mutagenic effects. However psoralen monoadducts are converted to cross links by higher doses of UV; angelicin monoadducts are not. The relevance of these results to psoralen photosensitization is discussed.Supported by the National Research Council of Canada. |
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