| 卡莫司汀缓释植入剂对S180肉瘤的抑制作用 |
| |
| 引用本文： | 张婕,宋加金,张红军,俞建江,苏红清,刘恩祥,赵云峰,孔庆忠. 卡莫司汀缓释植入剂对S180肉瘤的抑制作用[J]. 曲阜师范大学学报, 2007, 33(2): 106-109 |
| |
| 作者姓名： | 张婕 宋加金 张红军 俞建江 苏红清 刘恩祥 赵云峰 孔庆忠 |
| |
| 作者单位： | 山东大学生命科学学院;山东蓝金生物工程有限公司,250100,山东省济南市;曲阜师范大学科研处;山东蓝金生物工程有限公司,250100,山东省济南市;曲阜师范大学生命科学学院,273165,山东省曲阜市 |
| |
| 基金项目： | 山东蓝金生物工程有限公司资助项目;曲阜师范大学博士启动基金 |
| |
| 摘 要： | 以PLGA为载体的卡莫司汀缓释植入剂能有效抑制小鼠S180肿瘤的生长.含15%和25%卡莫司汀的缓释植入剂对肿瘤的抑制率分别为99%和98%(P<0.05).观察2个月发现,对照组小鼠平均存活时间为30.4天,15%卡莫司汀组小鼠平均存活52.7天(P<0.05),25%卡莫司汀组小鼠平均存活20天,瘤内注射组小鼠平均存活10天.
|
| 关 键 词： | 卡莫司汀 缓释植入剂 S180 肿瘤抑制 载体 聚乳酸 |
| 文章编号： | 1001-5337（2007）02-0106-04 |
| 修稿时间： | 2006-11-27 |
Inhibition in Slow-release Implants of Carmustine for S180 Sarcoma |
| |
| ZHANG Jie,SONG Jia-jin,ZHANG Hong-jun,YU Jian-jiang,SU Hong-qing,LIU En-xiang,ZHAO Yun-feng,KONG Qing-zhong. Inhibition in Slow-release Implants of Carmustine for S180 Sarcoma[J]. Journal of Qufu Normal University(Natural Science), 2007, 33(2): 106-109 |
| |
| Authors: | ZHANG Jie SONG Jia-jin ZHANG Hong-jun YU Jian-jiang SU Hong-qing LIU En-xiang ZHAO Yun-feng KONG Qing-zhong |
| |
| Affiliation: | 1 College of Life Science, Shandong University; 3 Lanjin BioPharm LTD, 250100, Jinan;3 Department of Sciencetific Research; 4 College of Life Science, Qufu Normal University, 273165, Qufu, Shandong, PRC |
| |
| Abstract: | The growth of S180 sarcoma in mouse is significant inhibited by BCNU-PLGA implants.Intralesional implantation of BCNU at 15% and 25% by weight in polymer result in a tumor growth inhibition of 99% and 98%(p< 0.05),respectively.Compared to control group(30.4 days),BCNU at 15% significantly extend the mean survival time to 52.7 days,observe in two months.BCNU at 25% administere intralesionally in polymer or in injection significantly inhibited tumor growth,which is debilitated by systemic toxicities and seen with BCNU in either formulations. |
| |
| Keywords: | S180 |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
