Distribution of the 1,25 dihydroxy-vitamin D3 receptor in the bursa of Fabricius of chicken |
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Authors: | M. Petrini F. Bianchi A. Dolfi M. Lupetti |
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Affiliation: | (1) Chair of Histology and Embryology, Faculty of Medicine, University of Pisa, Via Roma 55, I-56126 Pisa, (Italy);(2) Institute of Medical Clinic I, and Institute of Anatomy, University of Pisa, Via Roma 55, I-56126 Pisa, (Italy) |
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Abstract: | The vitamin D3 metabolite 1,25(OH)2D3 is probably involved in B lymphocyte ontogeny. We therefore determined the distribution of the 1,25(OH)2D3 receptor in the bursa of Fabricius and spleen cells of 7-day-old chicks, by immunohistochemistry using a monoclonal antibody against the chick intestinal cell 1,25(OH)2D3 receptor. The bursa cells of young (7-day-old) chicks contained large amounts of receptor while the spleen cells did not. The bursa cells of older (35-day-old) chicks contained fewer receptors, but the number of receptors in the spleen increased. |
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Keywords: | Vitamin D3 receptor dihydroxy-vitamin D3 bursa of Fabricius ontogeny of immune system B lymphocytes |
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