| 抗人体艾滋病毒的核糖体失活蛋白 |
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| 引用本文： | 郑永唐,贲昆龙.抗人体艾滋病毒的核糖体失活蛋白[J].大自然探索,1997(2). |
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| 作者姓名： | 郑永唐 贲昆龙 |
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| 作者单位： | 中国科学院昆明动物研究所 |
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| 基金项目： | 中国科学院重大应用项目,云南省应用基础研究基金 |
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| 摘 要： | 核糖体失活蛋白是一类作用于真核细胞核糖体，抑制蛋白质合成的毒蛋白。近年来，发现核糖体失活蛋白能抑制急性感染的Ｔ细胞和慢性感染的单核巨噬细胞中ＨＩＶ的复制和增殖，其作用方式独特，不产生耐药性。至少已知８种核糖体失活蛋白有抗ＨＩＶ的作用。这些核糖体失活蛋白的序列有一定的同源性
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| 关 键 词： | 核糖体失活蛋白 艾滋病 人免疫缺陷病毒 药物 |
RIBOSOME INACTIVATING PROTEINS WITH ANTI HUMAN IMMUNODEFICIENCY VIRUS ACTIVITIES |
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| Zheng Yongtang,Ben Kunlong.RIBOSOME INACTIVATING PROTEINS WITH ANTI HUMAN IMMUNODEFICIENCY VIRUS ACTIVITIES[J].Discovery of Nature,1997(2). |
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| Authors: | Zheng Yongtang Ben Kunlong |
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| Abstract: | Ribosome inactivating proteins (RIPs) are a large group of proteins that are potent inhibition of eukaryotic protein synthesis.Recently,at least 8 RIPs had been reported in literature to inhibit human immunodeficeincy rirus (HIV) replication in both acutely infected T cells and chronically infected macrophages.The mechanism of anti HIV activity of RIPs appears to be different from the known anti HIV drugs.RIPs do not induce resistant HIV strains.These RIPs are homomogous in sequence and probably evolutionarily related to each other. |
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| Keywords: | ribosome inactivating proteins acquired immunodeficiency syndrome human immunodeficiency virus drugs |
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