| 4＇-取代黄酮的合成及抗肿瘤活性研究 |
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| 引用本文： | 王学军,刘建利.4＇-取代黄酮的合成及抗肿瘤活性研究[J].甘肃科学学报,2014,26(6):51-55. |
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| 作者姓名： | 王学军 刘建利 |
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| 作者单位： | 1. 商洛学院生物医药工程系,陕西商洛,726000
2. 西部资源生物与现代生物技术省部共建教育部重点实验室,陕西西安,710069 |
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| 基金项目： | 国家自然科学基金，陕西省科技厅自然科学基金，陕西省教育厅项目基金，商洛学院人才引进基金 |
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| 摘 要： | 设计合成了12个4＇-取代黄酮衍生物（其中1个为新化合物）,其结构通过1 H NMR进行了表征.采用MTT法测定了这些化合物对Hela肿瘤细胞株的体外抗肿瘤增殖活性,初步的构效关系研究表明,黄酮母核的4’-位F取代时体外抗肿瘤活性强于其他3种基团取代,优选出的化合物7b具有潜在的抗肿瘤增殖活性,具有深入研究的价值.
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| 关 键 词： | 黄酮 合成 抗肿瘤活性 |
Synthesis and Antitumor Activities of 4'-Substituted Flavonoids |
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| WANG Xue-jun,LIU Jian-li.Synthesis and Antitumor Activities of 4'-Substituted Flavonoids[J].Journal of Gansu Sciences,2014,26(6):51-55. |
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| Authors: | WANG Xue-jun LIU Jian-li |
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| Institution: | WANG Xue-jun , LIU Jian-li ( 1. Department of Biomedical Engineering, Shangluo University, Shangluo 726000, China ; 2. Key Laboratory of Western Bioresource Biotechnology Attached to Ministry of Education, College of Life Science, Northwest University, Xi＇an 710069, China) |
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| Abstract: | Twelve flavone derivatives（one of them was new）were synthesized and the structures of them were characterized through ^1 H NMR. The in vitro anti-tumor activities of the derivatives against Hela cell lines were determined by MTT. Preliminary structure-activity relationship（SAR）studies indicated that the antitumor activities of 4CF replaced flavones were better than those of the other three substituted groups and compound 7b exhibited potentially high proliferation activity against Hela human cervical carcinoma cell lines. |
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| Keywords: | Flavone Synthesis Antitumor activities |
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