Molecular targets of glioma invasion |
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Authors: | M Nakada S Nakada T Demuth N L Tran D B Hoelzinger M E Berens |
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Institution: | (1) Cancer and Cell Biology Division, The Translational Genomics Research Institute, 445 North Fifth Street, Phoenix, Arizona 85004, USA;(2) Department of Neurosurgery, Division of Neuroscience, Graduate School of Medical Science, Kanazawa University, Ishikawa 920-0934, Japan |
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Abstract: | Glioblastoma multiforme is the most common and lethal primary malignant brain tumor. Although considerable progress has been
made in technical proficiencies of surgical and radiation treatment for brain tumor patients, the impact of these advances
on clinical outcome has been disappointing, with median survival time not exceeding 15 months. Over the last 30 years, no
significant increase in survival of patients suffering from this disease has been achieved. A fundamental source of the management
challenge presented in glioma patients is the insidious propensity of tumor invasion into distant brain tissue. Invasive tumor
cells escape surgical removal and geographically dodge lethal radiation exposure and chemotherapy. Recent improved understanding
of biochemical and molecular determinants of glioma cell invasion provide valuable insight into the underlying biological
features of the disease, as well as illuminating possible new therapeutic targets. These findings are moving forward to translational
research and clinical trials as novel antiglioma therapies.
Received 25 July 2006; received after revision 27 October 2006; accepted 22 November 2006 |
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Keywords: | Glioma invasion |
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