热休克蛋白(HSPs)基因家族在涡虫中的研究进展

热休克蛋白(HSPs)广泛存在于从细菌到人类的各种有机体中,在生物生命活动中具有重要生理功能,如作为分子伴侣参与细胞增殖和分化以及免疫应答等;同时某些HSPs表达水平的高低可作为衡量环境污染或者人类恶性肿瘤疗效和预后的重要指标.涡虫是扁形动物门的代表动物,因其在动物系统演化中的特殊地位和极强的再生能力而作为研究发育和再生的模式动物之一.概述了HSPs基因家族成员在涡虫抗逆和再生研究中的主要成果和最新进展,并对目前存在的问题及未来的发展方向进行了总结和展望.以期为揭示HSPs在高等动物中的作用机制提供参考.

Advances on HSPs Gene Family in Planarians

Heat shock proteins(HSPs)are ubiquitously found in all domains of life from bacteria to humans and play an important role in life,e.g.as a molecular chaperone involved in cell proliferation,differentiation and immune response,etc.;Moreover,the levels of HSPs expression may be used as a parameter of environment pollution or the therapeutic effect of malignant cancers and prognosis.Planarians possess extraordinary regenerative capacity and play an important role in studying the systematic evolution of animals,which make them one of the model animals for the investigation of regeneration and development.This paper review some major achievements and latest developments of HSPs in planarians to aim revealing the mechanisms of HSPs in stress responses and regeneration of planarians.