Suitability of urethane anesthesia for physiopharmacological investigations in various systems. Part 2: Cardiovascular system |
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| Authors: | C. A. Maggi A. Meli |
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| Affiliation: | (1) Pharmacology Department, Research Laboratories, A. Menarini Pharmaceuticals, Via Sette Santi 3, I-50131 Florence, Italy |
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| Abstract: | Summary Urethane produces a level of surgical anesthesia characterized by preservation of a number of cardiovascular reflexes. When the proper route of administration is used, and the use of unnecessarily high doses is avoided, urethane anesthesia appears to be suitable for a number of investigations at cardiovascular level. However in certain types of studies involving pharmacological stimulation of peripheral adrenoceptors urethane affects markedly the magnitude of the response under study. |
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| Keywords: | Urethane anesthesia physiology pharmacology in vivo experiments reflexes |
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