Choline accumulation in isolated rat hepatocytes |
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| Authors: | K. Yoshioka H. Nishimura |
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| Affiliation: | (1) Department of Medical Biochemistry, Shiga University of Medical Science, Seta, 520-21 Ohtsu, (Japan);(2) Department of Biochemistry, Kyoto Prefectural University of Medicine, 602 Kamikyo-ku, Kyoto, (Japan) |
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| Abstract: | Summary The accumulation of non-metabolized choline in isolated rat hepatocytes is concentrative in Na+ medium, whereas the accumulation does not exceed unity in a Li+ medium. Ouabain and 2,4-dinitrophenol inhibited the choline uptake. These results indicate that choline is taken up by rat hepatocytes via a Na+-and energy-dependent process, and choline oxidase is not directly connected with the choline transport system. |
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| Keywords: | Choline choline accumulation Na+-and energy-dependent process choline analogs quaternary ammonium compounds rat hepatocytes |
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