Elective induction in mice of solid and ascitic carcinoma of the exocrine pancreas by the repeated doses of antibodies against a lipoprotein lipase fraction]

Small doses, repeated for months of anti-esterase-lipoprotein antibodies, from several antisera raised against a crude lipoprotein-lipase from Rabbit adipose tissue (2), induce exocrine pancreatic carcinomas in mice, without any specific barrier. This seems to be the first case of a quite elective carcinogenic process of the pancreas, by an immunological mechanism, with a very high incidence, up to 100%. Such carcinomas are highly metastatic, produce a pancreatic carcinomatous ascites, and are deadly. This immunological pathogeny is discussed., more particulary on an action of immuno-complexes in an abnormal physiological environment.