磁热疗预防和治疗再狭窄研究进展

 冠心病是一种严重危害人类健康的心脏病，在中国的发病率和死亡率都呈上升趋势。经皮冠状动脉腔内成形术（PTCA）是治疗冠心病的常用方法，但PTCA术后6个月内血管再狭窄的发生率仍有30%～50%，严重影响了介入治疗的效果。目前，再狭窄的发生机制尚未完全明了。研究表明，再狭窄的机制之一是血管平滑肌细胞的过度增殖。已有研究证明热疗可以抑制血管平滑肌细胞的增殖，从而抑制血管再狭窄。利用外加磁场诱导支架升温抑制再狭窄发生是一种全新的治疗方法。磁热疗可使受热的细胞发生凋亡或细胞凝固性坏死，从而达到抑制组织过度增生的目的。该方法可重复治疗，无须再次手术，可显著减轻患者的痛苦，且对机体无其他不良刺激，是一种比较理想的治疗方法。本文综述了磁热疗对血管平滑肌细胞和内皮细胞的影响及其应用前景。

Progress in Preventing and Curing Restenosis by Magnetic Induction Hyperthermia

Coronary heart disease is a type of heart disease that poses serious risk to human health, and its incidence is greatly increasing in China. Percutaneous transluminal coronary angioplasty (PTCA) is widely used to treat patients with coronary artery disease. However, restenosis after PTCA, which occurs in 30%~50% of cases, is a severe problem that limits the efficacy of the intervention. Restenosis is a complex process caused by many factors, including elastic recoil of vessels, thrombosis, neointima formation, blood vessel wall remodeling, and inflammatory reactions. One of the most important steps in restenosis is the excessive proliferation of smooth muscle cells. Magnetic induction hyperthermia treatment offers a new approach to prevent and treat restenosis, by inhibiting the proliferation of vascular smooth muscle cells. Magnetic induction hyperthermia avoids the need for surgery, does not carry risk of adverse physical stimulation, and can reduce the suffering of patients. In this paper, we review the effects of magnetic induction hyperthermia on vascular smooth muscle cells and endothelial cells, and the clinical potential for this approach.