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Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis |
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| Authors: | Aulchenko Yurii S Hoppenbrouwers Ilse A Ramagopalan Sreeram V Broer Linda Jafari Naghmeh Hillert Jan Link Jenny Lundström Wangko Greiner Eva Dessa Sadovnick A Goossens Dirk Van Broeckhoven Christine Del-Favero Jurgen Ebers George C Oostra Ben A van Duijn Cornelia M Hintzen Rogier Q |
| Institution: | Genetic Epidemiology Unit, Department of Epidemiology and Biostatistics and Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands. |
| Abstract: | The few loci associated with multiple sclerosis (MS) are all related to immune function. We report a GWA study identifying a new locus replicated in 2,679 cases and 3,125 controls. An rs10492972C] variant located in the KIF1B gene was associated with MS with an odds ratio of 1.35 (P = 2.5 x 10(-10)). KIF1B is a neuronally expressed gene plausibly implicated in the irreversible axonal loss characterizing MS in the long term. |
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