HLA-G in organ transplantation: towards clinical applications |
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| Authors: | Frederic?Deschaseaux Diego?Delgado Vito?Pistoia Massimo?Giuliani Fabio?Morandi Email author" target="_blank">Antoine?DurrbachEmail author |
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| Institution: | 1.Etablissement Fran?ais du Sang,Tours,France;2.Heart Transplant Program, Peter Munk Cardiac Centre,Toronto General Hospital, University Health Network,Toronto,Canada;3.Department of Neurosciences, Ophthalmology and Genetics,University of Genoa,Genoa,Italy;4.INSERM U1014, Département de Néphrologie, H?pital du Kremlin-Bicêtre, IFRNT,Université Paris XI,Le Kremlin-Bicêtre,France |
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| Abstract: | HLA-G plays a particular role during pregnancy in which its expression at the feto–maternal barrier participates into the
tolerance of the allogenic foetus. HLA-G has also been demonstrated to be expressed in some transplanted patients, suggesting
that it regulates the allogenic response. In vitro data indicate that HLA-G modulates NK cells, T cells, and DC maturation
through its interactions with various inhibitory receptors. In this paper, we will review the data reporting the HLA-G involvement
of HLA-G in human organ transplantation, then factors that can modulate HLA-G, and finally the use of HLA-G as a therapeutic
tool in organ transplantation. |
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